Abstract: A variety of studies evidenced a relationship between drug use disorders and sexual dysfunction. In particular, heroin and opioid agonist medications to treat heroin dependence have been found to be associated with erectile dysfunction and reduced libido. Controversial findings also indicate the possibility of factors other than the pharmacological effects of opioid drugs concurring to s
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Newer generation e-cigarettes were perceived to be more satisfactory and more effective for refraining from smoking than older models. Women tended to use pre-filled, unmodified models, which were perceived by participants to be the least effective in terms of abstaining from smoking. This article is protected by copyright. All rights reserved….
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O objetivo deste artigo é descrever e analisar o trabalho de agentes comunitários de saúde (ACS), voltado para o desenvolvimento de práticas de atenção primária em saúde, relativas ao consumo prejudicial de drogas. O estudo partiu do referencial marxista e da metodologia da pesquisa-ação, o que conduziu à realização de 15 oficinas emancipatórias. O material foi analisado a partir da
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In this report, we further characterize the role of glucocorticoid and mineralocorticoid receptor (GR and MR) signalling in DA turnover at the Nacc, and in opiate withdrawal‐induced tyrosine hydroxylase (TH) expression, ERK and CREB phosphorylation (activation) in the nucleus of tractus solitarius (NTS‐A2). The role of GR and MR signalling was assessed with the selective GR antagonist, mifepri
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Abstract
The transition from casual to compulsive drug use is thought to occur as a consequence of repeated drug taking leading to neuroadaptive changes in brain circuitry involved in emotion and cognition. At the basis of such neuroadaptations lie changes in the expression of immediate early genes (IEGs) implicated in transcriptional regulation, synaptic plasticity and intracellular signalling. H
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