A Comparison of Neuropsychiatric Adverse Events During Early Treatment with Varenicline or a Nicotine Patch

ConclusionIn US VA patients studied prior to the boxed warning being implemented, use of varenicline for smoking cessation was not associated with a detectable increase compared with nicotine patches in hospitalization for any mental health outcomes. There was an increased rate of outpatient attendances with a primary diagnosis of schizophrenia amounting to 5 per 100 person years of treatment. Thi
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Authors: Wedam EF, Haigney MC
Abstract
Synthetic opioid agents have been used in modern medicine for over a century and for opioid addiction treatment for over a half-century. Liberal use of opioids in the United States has been attended by an extraordinary increase in opioid-related mortality, with over 16,000 deaths in 2012. As there have been advances in opioid agents for pain and addic
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CONCLUSION: When treated long-term and tested with CPP test of addiction, rats received chronic treatment ofcocaine became addicted. On the other hand, both doses ofcrude water extract of TL (1 and 10 g/kg, orally) did not cause significant changed in the time spent in both compartment between pre- and post-drug treatment indicating that TL did not cause addiction.
PMID: 26817209 [PubMed – in
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CONCLUSIONS: The core components of our approach-biopsychosocial assessment and multimodal treatment planning with an emphasis on promoting functional goals and safety using clear communication and a patient-centered stance-should guide providers in the management of similar clinical scenarios. More evidence is needed to definitively guide specific interventions and points of clinical equipoise.

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Authors: Vaughan CA, Pearsall I, Singh S, Windle B, Deb SP, Grossman SR, Yeudall WA, Deb S
Abstract
Human lung cancers harboring gain-of-function (GOF) p53 alleles express higher levels of the epidermal growth factor receptor (EGFR). We demonstrate that a number of GOF p53 alleles directly upregulate EGFR. Knock-down of p53 in lung cancer cells lowers EGFR expression and reduces tumorigeni
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