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Addiction 2016: As Heroin Use Escalates, A New Drug To Reverse Overdoses Hits US Drugstores …

Addiction 2016: As Heroin Use Escalates, A New Drug To Reverse Overdoses Hits US Drugstores …

At the very least, America’s roughly 12,000 local police departments and 14,500 … pilot program that has put naloxone in 10 addiction-related facilities. … Mitch Cunningham of the Wilmington Police Department in North Carolina, …
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[Cognitive impairments in alcohol dependence: From screening to treatment improvements].

Authors: Cabé N, Laniepce A, Ritz L, Lannuzel C, Boudehent C, Vabret F, Eustache F, Beaunieux H, Pitel AL
Abstract
Alcohol-related cognitive impairments are largely underestimated in clinical practice, even though they could limit the benefit of alcohol treatment and hamper the patient’s ability to remain abstinent or to respect his/her therapeutic contract. These neuropsychological defic
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Selective up‐regulation of functional mu‐opioid receptor splice variants by chronic opioids

Abstract
We recently reported (Verzillo, et al. J. Neurochem: 130, 790–796, 2014) that chronic systemic morphine selectively up‐regulates mRNA encoding two C‐terminal μ‐opioid receptor (MOR) splice variants, MOR‐1C1 and MOR‐1B2 (MOR‐1B2/‐1C1). Given the known disconnects between changes in levels of mRNA and corresponding protein, it is essential to directly demonstrate that chro
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Mechanisms of the psychostimulant effects of caffeine: implications for substance use disorders

A model that considers the striatal adenosine A2A-dopamine D2 receptor heteromer as a key modulator of dopamine-dependent striatal functions (reward-oriented behavior and learning of stimulus-reward and reward-response associations) is introduced, which should explain most of the psychomotor and reinforcing effects of caffeine. The psychostimulant properties of caffeine are reviewed and compared
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Which women are missed by primary health-care based interventions for alcohol and drug use?

CONCLUSIONS: As more than 40% did not have a USOC, with higher proportions among women with an APS, primary health-care based approaches to AEP prevention seem unlikely to reach the majority of women who have an APS and are at risk of an unintended pregnancy.
PMID: 26774493 [PubMed – in process] (Source: Addictive Behaviors)MedWorm Sponsor Message: Directory of the best January Sales in the UK
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