PPAR Agonists: I. Role of Receptor Subunits in Alcohol Consumption in Male and Female Mice

Blednov, Y. A., Black, M., Benavidez, J. M., Stamatakis, E. E. and Harris, R. A. (2016), PPAR Agonists: I. Role of Receptor Subunits in Alcohol Consumption in Male and Female Mice. Alcoholism: Clinical and Experimental Research. doi: 10.1111/acer.12976 Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas *Reprint requests: R. Adron Harris, PhD,
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ConclusionsThese studies indicate the complexity of EtOH‐dependent and EtOH‐independent behaviors that are altered by PPAR agonists and provide evidence for novel behavioral actions of these drugs that may contribute to PPAR‐mediated effects on alcohol drinking. (Source: Alcoholism: Clinical and Experimental Research)MedWorm Sponsor Message: Directory of the best January Sales in the UK. Fin
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ConclusionsThese data suggest that there is direct and selective involvement of the human FAAH C385A SNP and CB1 receptors in alcohol “binge” drinking.

Genotypic difference in alcohol intake in 4‐day drinking‐in‐the‐dark model (A) and alcohol preference on day 5 (B) in FAAH knock‐in mice: alcohol intake was recorded at 4‐h time point for 4 consecutive days in FAAHA/A, FAAHC/A, and
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ConclusionsHigher levels of exposure to AUF were associated with higher likelihood of alcohol use, binge drinking, and alcohol susceptibility in Latin American adolescents.

This study examines whether exposure to alcohol use in films is associated with alcohol use in 13,295 middle school students from public and private schools in two Latin American countries. This figure shows the crude associat
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Abstract
This review addresses current literature regarding health consequences associated with of a lifestyle or pattern of moderate drinking and the neurobehavioral effects of moderate drinking episodes in older adults. Discussed studies include both large-scale epidemiological investigations of the effect of moderate alcohol use on multiple health-related domains (e.g., cancer and card
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