Skip to content

Prairie Voles as a Model to Screen Medications for the Treatment of Alcoholism and Addictions

Prairie Voles as a Model to Screen Medications for the Treatment of Alcoholism and Addictions

Most preclinical studies of medications to treat addictions are performed in mice and rats. These two rodent species belong to one phylogenetic subfamily, which narrows the likelihood of identifying potential mechanisms regulating addictions in other species, ie, humans. Expanding the genetic diversity of organisms modeling alcohol and drug abuse enhances our ability to screen for medications to
See all stories on this topic

A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction

Publication date: Available online 21 March 2016 Source:International Review of Neurobiology Author(s): R.L. Bell, S. Hauser, Z.A. Rodd, T. Liang, Y. Sari, J. McClintick, S. Rahman, E.A. Engleman The purpose of this review is to present up-to-date pharmacological, genetic, and behavioral findings from the alcohol-preferring P rat and summarize similar past work. Behaviorally, the focus w
See all stories on this topic

Risk‐preferring rats make worse decisions and show increased incubation of craving after cocaine self‐administration

Abstract
Maladaptive decision‐making may play an integral role in the development and maintenance of an addiction. Substance‐dependent individuals make riskier choices on the Iowa Gambling Task, and these deficits persist during withdrawal and are predictive of relapse. However, it is unclear from clinical studies whether this cognitive impairment is a cause or consequence of drug use. We trai
See all stories on this topic

Sex differences in substance use disorders: focus on side effects

This article was aimed at reviewing sex differences in side effects induced by alcohol, nicotine, heroin, marijuana and cocaine and by medications approved for alcohol, nicotine and heroin use disorders. A large body of evidence suggests that women are at higher risk of alcohol‐induced injury, liver disease, cardiomyopathy, myopathy, brain damages and mortality. The risk of tobacco‐induced cor
See all stories on this topic

Internet-Based Interventions for Addictive Behaviours: A Systematic Review

Abstract
Internet-based interventions have emerged as a new treatment and intervention modality for psychological disorders. Given their features of treatment flexibility, anonymity and confidentiality, this modality may be well suited in the management of addictive behaviours. A systematic literature review of the effectiveness and treatment outcomes of Internet-based interventions for s
See all stories on this topic

Published inAddiction

Be First to Comment

Leave a Reply