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Specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 are non-oncogene addiction genes in cancer cells.

Specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 are non-oncogene addiction genes in cancer cells.

Authors: Hedrick E, Cheng Y, Jin UH, Kim K, Safe S
Abstract
Specificity protein (Sp) transcription factor (TF) Sp1 is overexpressed in multiple tumors and is a negative prognostic factor for patient survival. Sp1 and also Sp3 and Sp4 are highly expressed in cancer cells and in this study, we have used results of RNA interference (RNAi) to show that the three TFs individually play a role in
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Norharman and anxiety disorders.

Authors: Pepplinkhuizen L, Fekkes D, Timmerman L
Abstract
Norharman is a ß-carboline, possibly of endogenous origin, although cigarette smoking and food are sources too. In brain specific binding sites have been demonstrated. In higher doses norharman binds to benzodiazepine receptors and has MAO-B inhibitory activity. From animal experiments it can be concluded that norharman induces sed
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Service user and family member perspectives on services for mental health, substance use/addiction, and violence: a qualitative study of their goals, experiences and recommendations – Haskell R, Graham K, Bernards S, Flynn A, Wells S.

Click to Donate Now Your donation is safe and secure through the services of “Network for Good” a fund-raising platform for charities. Social and Epidemiological Research Department, Centre for Addiction and Mental Health, 200-100 Collip Circle, London, ON N6G 4X8 Canada ; Dalla Lana School of Public Health, University of Toronto, Toronto, ON Canada ; School of Psychology, Faculty of Health, Deak
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The relationship between controlled substances and violence – McGinty EE, Choksy S, Wintemute GJ.

Click to Donate Now Your donation is safe and secure through the services of “Network for Good” a fund-raising platform for charities. A causal relationship between controlled substances and firearm violence has been widely assumed in the United States, and federal law prohibits individuals who are “unlawful users of or addicted to any controlled substance” from purchasing or possessing firearms
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Current Epidemiology and Emerging Interventions for People With Co-occurring Mental Illness and Substance Use Disorders.

National Center for Biotechnology Information, U.S. National Library of Medicine 8600 Rockville Pike , Bethesda MD , 20894 USA…
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